IgG, under normal circumstances, is 6-16 g/L in adults. Elevated: chronic liver disease, subacute or chronic infection, connective tissue disease, IgG myeloma, asymptomatic monoclonal IgG disease, etc.
Reduction: hereditary or acquired antibody deficiency, mixed immunodeficiency syndrome, selective IgG deficiency, protein loss enteropathy, nephrotic syndrome, ankylosing muscular dystrophy, immunosuppressive therapy, etc.
IgA, under normal circumstances, is 760-3900 mg/L in adults. Increase: chronic liver disease, subacute or chronic infectious diseases (tuberculosis, fungal infection, etc.), autoimmune diseases (SLE, rheumatoid arthritis), cystic fibrosis, familial neutropenia, breast cancer, IgA nephropathy, IgA myeloma, etc.
Reduced: genetic or acquired antibody deficiency, immunodeficiency, selective IgA deficiency, none γ- Globulinemia, protein loss enteropathy, burns, anti IgA antibody syndrome, immunosuppressive therapy, late pregnancy, etc.
IgM, under normal circumstances, is 400-3450 mg/L in adults. Elevated: Fetal intrauterine infection, neonatal TORCH syndrome, chronic or subacute infection, malaria, infectious mononucleosis, mycoplasma pneumonia, liver disease, connective tissue disease, macroglobulinemia, asymptomatic monoclonal IgM disease, etc.
Reduced: genetic or acquired antibody deficiency, mixed immunodeficiency syndrome, selective IgM deficiency, protein loss enteropathy, burns, anti Ig antibody syndrome (mixed cryoglobulinemia), immunosuppression, etc.
Complement C3, C4. Under normal circumstances, C3 in human blood（ β The content of 1C globulin is 80-1550 mg/L, C4（ β The content of 1E globulin is 130-370 mg/L. The content and activity of blood complement can change in many pathological conditions, so dynamic observation of complement levels is necessary in clinical practice.
Increase: various inflammatory diseases, obstructive jaundice, acute myocardial infarction, ulcerative colitis, diabetes, acute gout, acute thyroiditis, acute rheumatic fever, dermatomyositis, polymyositis, mixed connective tissue disease, nodular periarteritis, etc.
Reduce: immune dysfunction or immunodeficiency; During ischemia, coagulation necrosis, and toxic necrosis, tissues release more proteolytic enzymes, leading to a decrease in complement hemolysis activity and complement grouping.
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Post time: Jan-20-2024